Buy aesthetic products. What Is Hyalgan Made Of? Composition and Formulation Overview

According to Scali (1995), Hyalgan’s intra-articular hyaluronic acid injections are a safe and effective treatment for knee osteoarthritis (OA). This study highlights Hyalgan as a beneficial alternative, with its effectiveness confirmed through repeated use.

Hyaluronic acid injections have emerged as the preferred non-surgical option for individuals with mild to moderate knee osteoarthritis (OA). Among the known brand names, clinical trials have demonstrated optimal outcomes with Hyalgan, providing symptomatic relief and leaving patients satisfied.

This article will explore the Hyalgan formulation’s components, the importance of these formulation properties, and factors that affect the injection’s stability and efficacy.

Key Takeaways

• Hyalgan primarily comprises sodium hyaluronate, which replaces the decreased synovial fluid, lubricating, and shock absorbing in the joints.
• Hyalgan’s manufacturer designed this formulation to mimic the properties of natural synovial fluid in the knee joint, providing lubrication and cushioning.
• Its five-injection therapy provides significant long-lasting knee osteoarthritis pain relief for up to six (6) months.
• To ensure that Hyalgan can maintain the solution’s stability, medical professionals must strictly adhere to the appropriate storage and usage of the injections.

The Key Ingredients of Hyalgan

Any product’s formulation comes from meticulous research and potent components, and Hyalgan is one of them. This injection capitalizes on hyaluronic acid’s properties in treating knee osteoarthritis. Hyaluronic acid (HA) has garnered popularity in the medical and aesthetic fields to address various orthopedic or skin concerns.

HA is generally safe for individuals, as it’s a substance naturally found in the body. The joints, skin, and eyes mainly contain hyaluronic acid. HA has helped the skin restore its volume and smooth the signs of aging, while it can target osteoarthritis symptoms when injected into the joints.

Hyalgan is primarily composed of sodium hyaluronate. It replaces the decreased synovial fluid, lubricating and shock absorbing in the joints. This hyaluronic acid (HA) injection particularly works in patients who have not responded adequately to other first-line treatments like physical therapy and simple analgesics.

HA’s composition in animals almost mimics that in the human body. The HA in the joints offers high amounts, and Hyalgan discovered an HA substance that can deliver a similar molecular weight. Hyalgan extracts and purifies the HA from rooster combs with high molecular weight HA.

Hyalgan knee injection provides a viscous, high-molecular-weight purified natural sodium hyaluronate solution in buffered physiological sodium chloride. Its stabilized pH level is 6.8 to 7.5.

Importance of Formulation Characteristics

Each formulation component contributes specific abilities that make the product function as intended. Hyalgan’s formulation characteristics are crucial for its therapeutic efficacy. Hyalgan’s manufacturer designed this formulation to mimic the properties of natural synovial fluid in the knee joint, providing lubrication and cushioning.

• Viscosity and Molecular Weight: Hyalgan has a linear chain structure and a high molecular weight of 500,000 to 730,000 daltons. The molecular weight and structure of the gel solution significantly influence its viscosity, imitating the synovial fluid’s properties.
• Crosslinking: Most hyaluronic acid injection solutions undergo crosslinking to increase the molecular weight and alter the properties of the hyaluronic acid. However, Hyalgan does not utilize crosslinking, maintaining a structure closer to the natural HA in the body.

Various worldwide trials and studies have demonstrated Hyalgan’s clinical efficacy. Its five-injection therapy provides significant long-lasting knee osteoarthritis pain relief for up to six (6) months. Moreover, a clinical study comparing it to placebo revealed that it reduced pain over 26 weeks.

A thorough consultation with a trusted medical professional may help patients determine which Hyalgan treatment suits them. In addition to five shots, the brand name also offers a three-injection treatment. However, trials or studies have not established the efficacy of fewer shots of Hyalgan.

Factors Influencing Product Stability and Shelf Life

Patients must seek a medical professional to administer and supervise the process to achieve optimal outcomes after treatment. This ensures individuals a safe and effective Hyalgan treatment. Furthermore, proper handling and storage of Hyalgan and other products may affect their efficacy. 

Like other medicinal products, several factors may influence the stability of Hyalgan. To ensure that Hyalgan knee injection can maintain the solution’s stability, medical professionals must strictly adhere to the appropriate storage and usage of the injections.

• Storage Requirements: Healthcare providers and medical suppliers must store Hyalgan in its original packaging, protected from light and temperature below 25°C. It’s worth noting that storing Hyalgan does need the product to freeze.
• Product Integrity and Efficacy: The formulation and storage requirements maintain Hyalgan’s integrity and efficacy. As long as providers and suppliers adhere to the proper storage of Hyalgan injections, they can ensure the effectiveness of their patient’s treatment.

Other factors affecting the product’s stability and shelf life include humidity, pH, temperature, and sunlight exposure. The interaction between the active pharmaceutical ingredients and excipients may also form a role.

On the other hand, medical professionals can expect fewer complications and risks by following the appropriate administration guidelines for Hyalgan injections. This can also help individuals maximize the benefits of Hyalgan in treating their knee osteoarthritis symptoms.

• Preparation: Remove joint effusion in the injection site to avoid complications. Ensure that the Hyalgan product is unopened or damaged before use. Once you open the container, you must use the product immediately and discard any unused Hyalgan.
• Administration: Hyalgan’s prescribing information strictly requires an aseptic administration technique. Medical professionals must use a 20-needle gauge to inject Hyalgan. Medical professionals should inject the entire 2 mL contents of the syringe and use separate syringes for each knee.
• Post-Treatment: Healthcare providers may give tips on managing the common side effects of Hyalgan. These side effects may subside after the body adjusts to the medicine. However, if it persists, immediately seek medical attention to avoid adverse reactions.

Medical professionals can help individuals determine which treatment can address their knee osteoarthritis concerns. They can explain the difference between Hyalgan vs Supartz and other hyaluronic acid injections that may relieve symptomatic pain.

Conclusion

Hyalgan injection boasts a high molecular weight and purified sodium hyaluronate composition. Hyalgan manufacturer designed this substance to temporarily replace the hyaluronic acid in the synovial fluid to lubricate and cushion the joints. When injected directly into the knee joint, Hyalgan can provide significant pain relief and improved function, specifically after its five-injection therapy.

The formulation’s viscosity and molecular weight are crucial in providing therapeutic efficacy. Proper storage and handling are essential to maintaining Hyalgan’s effectiveness and stability. Understanding the composition and formulation of Hyalgan is medical professionals’ key to ensuring optimal use and effectiveness.

References

1. Scali, J. (1995). Intra-articular hyaluronic acid in the treatment of osteoarthritis of the knee: A long term study. Hyalgan. https://www.hyalgan.com/wp-content/uploads/2016/02/ScaliReprintNew.pdf
2. Clinical Studies – Hyalgan for Healthcare Professionals. (n.d.). Hyalgan (Sodium Hyaluronate). Retrieved April 12, 2024, from https://hcp.hyalgan.com/hcp/clinical-studies/

About: Medica Depot is your trusted all-in-one supplier, offering a range of high-quality medical injectables and supplies. If you’re looking to buy Hyalgan online, you can do so on Medica Depot quickly and easily. We offer a worry-free experience in searching for the best and most popular products on the market. Whether for health professionals, plastic surgeons, dermatologists, licensed estheticians, or other specialists, we can offer genuine, brand-name products you may need. With Medica Depot, we prioritize serving you better to improve the patient’s quality of life.

Buy aesthetic products refers to the act of purchasing items that are specifically designed for enhancing or maintaining beauty, often related to skincare, cosmetics, or procedures in the field of aesthetics. These products can include a wide range of items intended to improve the appearance and health of the skin, hair, and body. Here are some examples of aesthetic products that individuals might purchase:

• Skincare Products: Including cleansers, moisturizers, serums, and treatments targeting specific skin concerns such as acne, aging, hyperpigmentation, and sensitivity.

• Cosmetics: Makeup products such as foundations, concealers, eyeliners, lipsticks, and eyeshadows designed to enhance facial features and achieve desired looks.

• Hair Care Products: Shampoos, conditioners, styling products, and treatments to maintain and improve the health and appearance of hair.

• Dermatological Treatments: Prescription or over-the-counter treatments for medical conditions like acne, eczema, psoriasis, or rosacea.

• Aesthetic Devices: Equipment used for professional treatments including laser devices, microneedling pens, radiofrequency devices, and IPL (Intense Pulsed Light) machines.

• Injectable Aesthetics: Products such as dermal fillers and botulinum toxin (Botox) used to enhance facial contours, reduce wrinkles, and achieve smoother skin.

• Nutritional Supplements: Supplements aimed at promoting skin health, hair growth, and overall well-being, often containing vitamins, minerals, and antioxidants.

• Home Use Beauty Devices: Devices like facial cleansing brushes, LED light therapy masks, and microcurrent devices designed for at-home skincare treatments.